Peroxisome proliferator-activated receptor α-independent peroxisome proliferation

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概要

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• Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor α (PPARα) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPARα-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPARα dependence in the assay system. Surprisingly, a novel type of PPARα-independent peroxisome proliferation and enlargement was uncovered in PPARα-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11α, might be associated with the PPARα-independent peroxisome proliferation at least in part.

• ACADEMIC PRESS INC ELSEVIER SCIENCEの論文
• 2006-08-11

著者

• Kamijo Yuji

  Dep. Of Metabolic Regulation Inst. On Aging And Adaptation Shinshu Univ. Graduate School Of Medicine

• Kamijo Yuji

  信州大学 医学部2内科

関連論文

• Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
• Peroxisome proliferator-activated receptor α-independent peroxisome proliferation

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