One pot synthesis of optically active 4-isoxazolines by asymmetric addition of alkynylzinc reagents to nitrones followed by cyclization
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概要
- 論文の詳細を見る
One pot synthesis of optically active 4-isoxazolines was achieved by asymmetric addition of alkynylzinc reagents to nitrones utilizing di(t-butyl) (R,R)-tartrate as a chiral auxiliary followed by cyclization. By addition of dimethylzinc, the cyclization step was accelerated to afford the corresponding 4-isoxazolines with up to 93% ee. Furthermore, a cyclized zinc intermediate could be trapped with formaldehyde to give the corresponding 2,3,4,5-tetrasubstituted 4-isoxazoline with 85% ee. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
- Elsevier BV / Japan Institute of Heterocyclic Chemistryの論文
- 2009-03-01
著者
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Ukaji Yutaka
Kanazawa Univ. Kanazawa Jpn
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Ukaji Yutaka
Department Of Chemistry Faculty Of Science Kanazawa University Kakuma
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Ukaji Yutaka
Department Of Chemistry Faculty Of Science Kanazawa University. Department Of Chemical Science Gradu
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Ukaji Y
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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KOBAYASHI Masato
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University
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