実験的肺結核症に就て
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概要
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In this report on the experimental pulmonary tuberculosis, the part which has closer application to clinical use is selectively discussed. This experiment was based upon the comparative histopathological study of the two groups of rabbits, one of them infected by tubercle bacillus (human-type, freshly separated) through the trachea and the other subcutaneously sensitized before the per tracheal infection. Generally, the results were similar to the "Koch's Phenomenon"; but tuberculous lobar pneumonia with the formation of cavities was noted in some of these animals because the used bacillus was of a high virulent strain. Although, the tuberculous allergy was ascertained in this experiment, allergic change of the blood vessels, for example the fibrinoid degeneration of the vessels, was not recognized. However adventitial round cell infiltration may be considered as the allergic reaction due to tuberculosis. Wellknown vascular change in pulmonary tuberculosis is nothing but the productive endangitis in the infected areas of the lung and we have recognized stricture or obstruction of the vessels from its very early stage. Arteriography revealed that loss or narrowing of the arteriograms in the infected portion are seen in proportion to the grade of the infection. It was confirmed that in the earlier stage after the infection the blood circulation is less disturbed. In connection with the use of anti-tuberculous medicines, such as INAH, PAS and Tb-I, we have histologically found that the most effective cases in tuberculous rabbits were those, treated soon after the inoculation, which had less grade of the tissue invasion viz. less change of the blood vessels. Emergence of the tuberculous shadow in the lung on the roentgenogram has been traced and it was found out that the treatment after the emergence of the shadow has very little effect on the cure. Transition of the Mantoux-Reaction from negative to positive appeared earlier than the emergence of the X-ray shadows in our experiment, and considerable effect was obtai
- 千葉医学会の論文