ダンシルグリシン修飾シクロデキストリンの生理活性物質に対する分子認識センサ-能

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概要

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• Dansyl-modified β-, γ-cyclodextrins (1 and 2) have been prepared as a sensor for detectingbioactive-organic compounds such as steroids and alkaloids. 1 shows pure monomer fluorescencewhose intensity is decreased upon addition of guest species. However, 2 shows two typesof pure monomer fluorescence, that is, one is the same for the case of 1, the other is whoseintensities is enhanced upon addition of guest species. This guest-induced variation in thefluorescence intensity suggests that the dancylglycine moiety acts as a spacer which enables thecyclodextrin to form 1 : 1 host complexing by narrowing the large γ-cyclodextrin cavity. Thevalue △I/I°, where I and ro are fluorescence intensities in the presence and absence of a guestand △I is 1°-I is fluorescence parameter. 1 exhibits higher selective and sensitive molecularrecognition ability for steroids and alkaloids except for lithocholic acid than does 2.

• 秋田大学鉱山学部の論文

著者

• 浜田 文男

  Department of Fuel Chemistry, Mining College, Akita University

関連論文

• UNIQUE BINDING BEHAVIOR OF γ-CYCLOEXTRIN BEARING A FERROCENE MOIETY
• ダンシルグリシン修飾シクロデキストリンの生理活性物質に対する分子認識センサ-能

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