Palladium(II)-catalyzed 1,4-addition of arylboronic acids to β-arylenals for enantioselective syntheses of 3,3-diarylalkanals: a short synthesis of (+)-(R)-CDP 840
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概要
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Table Schem Fig Revised1,4-Addition of arylboronic acid to trans-β-arylenals proceeded smoothly in acetone–water (10/1) at 10–25 °C in the presence of [Pd(S,S-chiraphos)(PhCN)2](SbF6)2 (0.5 mol %), AgX (X = BF4, SbF6, 10 mol %) and aqueous 42% HBF4 to afford optically active 3,3-diarylalkanals with high enantioselectivities in a range of 86–97% ee. The protocol provided a method for short-step synthesis of optically active (+)-(R)-CDP 840.
- Elsevier Ltd.の論文
- 2007-06-04
著者
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Yamamoto Yasunori
Division Of Chemical Process Engineering Graduate School Of Engineering Hokkaido University
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NISHIKATA Takashi
Innovation Plaza Hokkaido, Japan Science and Technology Agency
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MIYAURA Norio
Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University
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Miyaura Norio
Division Of Chemical Process Engineering Graduate School Of Engineering Hokkaido University
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Nishikata Takashi
Innovation Plaza Hokkaido Japan Science And Technology Agency
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