N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin
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概要
- 論文の詳細を見る
N-Glycan oligosaccharides are thought to play multiple, important roles in a variety of biological events. However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail. To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients. Chromatograms of patient scale samples showed unique alterations in three peaks eluted at 15.8, 18.8 and 26.9 min. The N-glycan profiles were significantly altered in ichthyotic hyperkeratotic skin compared with normal non-hyperkeratotic controls. These findings indicate the reduction of N-acetylglucosaminyltransferase II and fucosyltransferase 8 activities. Alteration of N-glycan structures in hyperkeratotic skin suggests the biological role of N-glycans in keratinization.
- Springerの論文
著者
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Nishimura S
Graduate School Of Advanced Life Science Frontier Research Center For Post-genomic Science And Techn
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Ito Hiroki
Hitachi High-technologies Company
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Nishimura Shin-ichiro
Graduate School Of Advanced Life Science Frontier Research Center For Post-genomic Science And Techn
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Nishimura Shin-ichiro
Laboratory For Bio-macromolecular Chemistry Frontier Research Center For Post-genomic Science And Te
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Nakagawa Hiroaki
Graduate School Of Advanced Life Science Frontier Research Center For Post-genomic Science And Techn
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Deguchi Kisaburo
Graduate School Of Advanced Life Science Frontier Research Center For Post-genomic Science And Techn
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