Influence of intravenous sedation with midazolam on Respiratory　function and muscle activity inelderly and young patients

概要

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Objective: The purpose of this study was to investigate the optimal dosage of intravenous midazolam for sedation in elderly patients and compare the amount of depression of respiratory function and skeletal muscle activity after obtaining similar sedation levels in younger patients.Patients and Methods: Fifteen elderly patients older than 65 years (group E) and 15 patients younger than 55 years (group Y) underwent oral surgery or dental treatment with or without local anaesthesia after intravenous administration of midazolam.Results: The optimal dose for the elderly patients was 62% that for the younger patients. The duration of depression of arterial oxygen saturation and vital capacity was more prolonged among patients in group E than in those in group Y. The number of patients whose grip strength value recovered 15 and 30 minutes after administration of midazolam was significantly smaller for group E than for group Y.Conclusion: These results suggest that elderly people should be carefully treated with attention to the decrease in skeletal muscle activity, including respiratory and upper airway muscles, when receiving intravenous sedation with midazolam.
Scientificの論文
2002-12-01