Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
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概要
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The non-classical, but frequently reported behavior of GABA[A] receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity in progress. From the perspective of a dynamical systems approach, such "excitatory" GABAergic responses may serve to temporarily invoke attractor-like memories when extensively activated by, for example, top-down signals as category information or attention, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory structure back to attractor ruins.http://www.worldscinet.com/jin/jin.shtml
- Imperial College Pressの論文
Imperial College Press | 論文
- Prologue - the work of the late professor Gen Matsumoto
- Functional relevance of 'excitatory' GABA actions in cortical interneurons : a dynamical systems approach
- Chaotic itinerancy as a mechanism of irregular changes between synchronization and desynchronization in a neural network