Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
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概要
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The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associatednuclear antigen (LANA) is known to modulate viral and cellular gene expression. Weshow that LANA directly associates with an IL-6 signal transducer, STAT3 and thatLANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studiesdocumented a physical interaction between LANA and STAT3 in transiently transfected293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line.Furthermore, small-interfering RNA-mediated reduction of LANA expression decreasedthe STAT3-dependent transcription in KSHV-positive PEL cells, whereasoverexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphomacells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, andmay have implications for the pathogenesis of KSHV-associated diseases.
- Federation of European Biochemical Societies Published by Elsevier B.V.の論文
Federation of European Biochemical Societies Published by Elsevier B.V. | 論文
- Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
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