Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma
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概要
- 論文の詳細を見る
Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue.
- Blackwell Publishingの論文
著者
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Kondo Satoshi
斗南病院 外科
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Katoh Hiroyuki
Department Of Surgery Tonan Hospital
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Kawarada You
Department Of Surgery Tonan Hospital
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Kawarada You
斗南病院 外科
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Kawarada Yo
Division Of Cancer Medicine Surgical Oncology Hokkaido University Graduate School Of Medicine
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Kondo S
Atomic Energy Research Institute Kinki University
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Morikawa Toshiaki
Department Of Surgical Oncology Hokkaido University Graduate School Of Medicine
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Morikawa Toshiaki
Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M
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Kawakami Hiroshi
Hokkaido Univ. Graduate School Of Medicine Sapporo Jpn
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Katoh Hiroyuki
Department Of Surgical Oncology Hokkaido University School Of Medicine
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Katoh Hiroyuki
Department Of Surgical Oncology Hokkaido University Graduate School Of Medicine
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Shichinohe Toshiaki
Department Of Surgical Oncology Hokkaido University Graduate School Of Medicine
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