Stereoselective synthesis of a C1-C6 fragment of pinnatoxin A via a 1,4-addition/alkylation sequence

スポンサーリンク

概要

• 論文の詳細を見る

• A C1–C6 fragment of pinnatoxin A, (5S,6R)-5,6-dimethyl-3-methyleneoxepan-2-one, which features a γ,δ-trans-dimethylsubstituted α-methylene lactone, has been synthesized in an optically pure form from ethyl (E)-4-benzyloxy-2-butenoate through an auxiliary-based conjugate addition and alkylation reaction. The excellent diastereoselectivity (98:2) observed in the alkylation reaction would be a result of stereocontrol from both the adjacent stereocenter and the chiral oxazolidinone.

• Pergamonの論文
• 2008-05-16

著者

• Hashimoto Shunichi

  Fac. Of Pharmaceutical Sciences Hokkaido Univ.

関連論文

• Stereoselective synthesis of a C1-C6 fragment of pinnatoxin A via a 1,4-addition/alkylation sequence
• P-24 TOTAL SYNTHESIS OF POLYGALOLIDES A AND B

スポンサーリンク