Progressive Multifocal Leukoencephalopathy (PML) in A Japanese Patient with Acquired Immunodeficiency Syndrome (AIDS) : A Case Report

概要

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We report an autopsy case of progressive multifocal leukoencephalopathy (PML) of a 40 year-old Japanese male with acquired immunodeficiency syndrome (AIDS). Since he was diagnosed as hemophilia A at the age of 15 years, he had been treated with factor VIII concentrates. When he was 35 years old, the antibody against human immunodeficiency virus (HIV) was found to be positive. Four years later he was pointed out left hemiparesis. Pneumocystis carinii organisms were detected and he was diagnosed as AIDS at the age of 40 years. During his admission multiple lesions were demonstrated in the cerebral white matter by MRI and CT scan and suspected to be PML. Dyspnea aggravated rapidly and he died from respiratory failure. Autopsy examination revealed multiple necrotic foci in the cerebral white matter, which showed characteristic histological features to be confirmed as PML, namely, multiple demyelinating foci with enalrged and bizarre astrocytes, hypertrophied oligodendrocytes with intranuclear inclusion bodies and numerous lipid-laden macrophages.
長崎大学熱帯医学研究所の論文
1994-10-30