肝炎・肝硬変および肝癌に経る相互関係の統計による分析

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ケニア国の剖検例の肝臓を用いて,肝炎・肝硬変および肝癌とB型肝炎ウイルスの相互関係を統計により分析を試みた. B型肝炎ウイルスの感染が全体に29%,肝硬変に69%,肝癌に82%の割合で存在することが解った.統計による分析の結果,肝炎・肝硬変および肝癌の相互関係は高い相関が認められた.Hepatocellular carcinoma becomes clinically manifest after cirrhosis has been well formed, and the major factor predisposing hepatocellular carcinoma in a population appears to be the presence of cirrhosis caused by chronic hepatitis B virus infection in that population. Co factors in hepatocarcinogenesis such as foodstuffs contaminated by aflatoxin, probably play a secondary role in the development of hepatocellular carcinoma even a country like where Kenya occurs in a high incidence of chronic hepatitis B virus infection. Therefore, we tried statistically to confirm the above hypothesis using iver specimens obtained from Kenya, and verified significant associations between hepatitis B surface antigen, cirrhosis and hepatocellular carcinoma.
長崎大学熱帯医学研究所の論文
1984-09-29