Transdermal Device of a Substituted Benzimidazole Carbamate and its Efficacy Against Helminth Parasites
スポンサーリンク
概要
- 論文の詳細を見る
The anthelmintic efficacy of a substituted benzimidazole carbamate (methyl-5-[4-(2-pyridinyl)-1-piperazinyl]-1 H-benzimidazole-2yl-carbamate) in an adhesive diffusion controlled matrix was assessed against adult and larval forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid) and Hymenolepis nana (tape worm). Tapes impregnated with 5 mg of compound and applied on the dorsum of hamster resulted in complete elimination of adult A. ceylanicum. Against the metamorphic forms of this parasite, the reduction rate was 66.9%, 90.4% and 92.6% against L_3, L_4 and L_5 stages respectively. Remarkable efficacy through this delivery system was also noticed against N. brasiliensis and H. nana. The transdermal drug delivery is the first attempt in the helminth chemotherapy and could beneficially be extended to clinical conditions.
- 長崎大学熱帯医学研究所の論文
- 1992-09-30
長崎大学熱帯医学研究所 | 論文
- あらためて物理的バリアーを考える (第2部 研究集会) -- (感染症制圧をめざしたベンチャービジネス)
- HIV感染症の変貌とその対策
- ミニブタを用いたヒト住血吸虫症モデルの確立と応用
- 熱帯感染症に対する宿主感受性を決定する遺伝子多型の解析
- シャーガス病の病態に関する免疫遺伝学的研究