Prevention of Japanese Encephalitis (JE) by BIKEN Vaccine and Epidemiological Survey on JE in Dong Anh District, Hanoi, Vietnam

概要

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From January 1986 to 1988, a total 27, 700 children between 3 months to 5 years old (85.7% of the target poopulation) in Dong Anh Distict, Hanoi, Vietnam, were immunized with JE BIKEN vaccine. The number of 24 JE cases reported from 1986 to 1988 after the vaccination was significantly less than the number of 131 cases reported in the years 1984 and 1985 before the vaccination. After the vaccination, annual number of JE cases was reduced more than 8-fold compared with previous years, and 21 of the 24 of JE cases (87.5%) were found among unvaccinated. Surveillances on swine antibodies and mosquito population in 1988-1989 indicated continued transmission of JE virus in the study area. By the hemagglutination-inhibition (HI) test, antibody positive swine were found all year round, and the positve rate fluctuated between 10 to 66% (average 43.5%) with gemoetrical mean titer between 11-47. Culex tritaeniorhynchus was the most abundant mosquito species and its density increased in hot season particularly in April and August, while its density was low in January to March and October to December.
長崎大学熱帯医学研究所の論文
1991-12-20