The Uptake of 5-Hydroxytryptamine by Litomosoides carinii and the Effect of Antifilarials
スポンサーリンク
概要
- 論文の詳細を見る
Litomosoides carinii, the filarial parasite of cotton rat (Sigmodon hispidus), has been shown to possess both high and low affinity uptake mechanisms for 5-hydroxytryp-tamine (5-HT). The Michaelis-Menten constant (K_m) and Vmax values for high affinity system were 1.9 μM and 1.25 μM/g/2 min, while the corresponding values for the low affinity system were 10 μM and 6.6 μM/g/2 min respectively. The uptake mechanism was found to be temperature dependent and was inhibited by microfilaricides-diethylcar-bamazine and centperazine, the latter exhibiting more pronounced effect. The filarial worms could not synthesize 5-HT from its precursor amino acid, tryptophan.
- 長崎大学熱帯医学研究所の論文
- 1987-12-28
長崎大学熱帯医学研究所 | 論文
- あらためて物理的バリアーを考える (第2部 研究集会) -- (感染症制圧をめざしたベンチャービジネス)
- HIV感染症の変貌とその対策
- ミニブタを用いたヒト住血吸虫症モデルの確立と応用
- 熱帯感染症に対する宿主感受性を決定する遺伝子多型の解析
- シャーガス病の病態に関する免疫遺伝学的研究