Acanthocheilonema viteae in Mastomys natalensis : Contents of Certain Biogenic Amines in Brain and Other Peripheral Tissues following Diethylcarbamazine Treatment.

概要

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The effect of diethylcarbamazine (DEC) treatment on the concentration of histamine (H) and some other biogenic amines namely dopamine (DA), norepinephrine (NE), epinephrine (E) and 5-hydroxytryptamine (5-HT) has been investigated in different brain regions and some peripheral tissues of normal and Acanthocheilonema viteae infected adult Mastomys natalensis. During Acanthocheilonema viteae infection histamine level increased significantly in cerebral hemispheres, mid-brain hypothalamus, lungs. The levels of monoamines were unaffected. Histamine level significantly increased in all the organs studied, except adrenal glands, three hours after diethylcarbamazine (DEC) treatment on normal as well as filaria-infected mastomys. Enhancement in histamine level of tissues after DEC treatment was not responsible for development of allergic reactions in infected animals. Nevertheless changes in hypothalamic histamine concentration may be involved in the genesis of DEC induced fever.
長崎大学熱帯医学研究所の論文
1991-06-29