Mechanisms of Acquired Immunity against Brugia pahangi : Inflammatory Cell Responses and Antibody Formation Following the Challenge Infection in Mice Immunized with Naive Infective Larvae

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The mechanisms of resistance of immunized BALB/c mice to intraperitoneally challenged B. pahangi were examined. Mice developed significant resistance to challenge infection by immunization with naive B. pahangi infective larvae. Remarkable resistance was already established at 5 weeks after immunization and persisted at least until 12 weeks. Resistance in immunized mice appeared at the early phase of challenge infection (5 days post-inoculation) and became more remarkable on day 10 and 15 post-inoculation. Immunized mice showed higher inflammatory cell (lymphocytes, macrophages and eosinophils) responses against B. pahangi challenge infection than control mice at 5 and 10 days post-infection. At that time, immunized mice showed high levels of anti-B. pahangi IgG and IgM antibodies. Moreover, many killed or weakened larvae encapsulated with inflammatory cells (macrophages and eosinophils were predominant) were observed in the peritoneal cavities of immunized mice. These results suggest that the significant resistance to challenge infection in mice immunized by naive B. pahangi infective larvae is due to developed inflammatory cell responses and coexistence of specific antibodies.
長崎大学熱帯医学研究所の論文
1989-03-31