Unchanged Susceptibility of Jird (Meriones unguiculatus) with Existing Brugia pahangi Infection to Schistosoma mansoni Infection

概要

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The effect of existing Brugia pahangi infection on the susceptibility of jirds to Schistosoma mansoni infection was studied. The jirds with existing acute and chronic B. pahangi infection were infected with S. mansoni cercariae. They were examined for eggs in the stool on day 36 postinfection and afterwards. On day 70, they were sacrificed for the examination of adult worms. On the basis of the prepatent period, EPG and percent recovery of worms, the susceptibility of jirds with acute B. pahangi infection to S. mansoni was not different from that of control jirds. Although, on day 57 postinfection EPG of jirds with chronic B. pahangi infection was statistically higher than that of control jirds, the prepatent period, EPG on days 43, 50, 64 and worm recovery were not different between jirds with chronic filarial infection and control. The filaria-induced nonspecific depression of immunoresponsiveness, which had been reported by many parasitologists so far, does not enhance the susceptibility of jirds to S. mansoni infection.
長崎大学熱帯医学研究所の論文
1989-03-31