EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA
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The effect of fenofibrate in type 2 diabetic patients with dyslipidemia was examined. Thirteen patients with type 2 diabetes mellitus and mixed hyperlipidemia; serum total cholesterol (TC)>220 mg/dl and/or triglyceride (TG)>150 mg/dl, were included in the study. Fenofibrate was administered at daily dose from 200 to 300 mg, and following items were implemented just prior to, at 3 months after, and at 6 months after the administration: amount of serum lipid, electrophoresis of lipoprotein by the method of polyacrylamide gel electrophoresis (PAGE), quantification of cholesterol (RLP-C) and triglyceride (RLP-TG) in remnant-like particle. TC significantly decreased at 6 months after administration (p<O.05), while TG at 3 and 6 months after administration was significantly lowered (p<0.05). Concentration of RLP-C that was 16.3 mg/dl before administration of fenofibrate decreased with statistical significance to attain 6.2 mg/dl and 7.2 mg/dl in 3 and 6 months after administration, respectively (p<0.01). In the case of RLP-TG, the concentration of 92.2 mg/dl before administration was observed to be lowered with time with statistical significance to reach 28.7 mg/dl and 32.7 mg/dl in 3 and 6 months, respectively (p<0.01). The low-density lipoprotein (LDL) particle size significantly increased at 6 months after administration (p<0.05). In all cases the remnant lipoprotein was observed on PAGE before administration, the bands disappeared or decreased in 8 cases by the treatment with fenofibrate. It was suggested that fenofibrate lowered RLP-C and RLP-TG, and improved the LDL particle size in type 2 diabetics with dyslipidemia.
- 弘前大学医学部・弘前医学会の論文
- 2004-03-31
弘前大学医学部・弘前医学会 | 論文
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