Effect of Immobilization on Insoluble Collagen Concentration and Type I and Type III Collagen Isoforms of Rat Soleus Muscle
スポンサーリンク
概要
- 論文の詳細を見る
Immobilization is often associated with decreased muscle elasticity. This condition is known as muscle contracture; however, the mechanism remains unclear. The purpose of this study was to clarify the mechanism governing muscle contracture in rat soleus muscle by identifying changes in ankle joint mobility, insoluble collagen concentration and type I and type III collagen isoforms following 1- and 3-week immobilizations. Following a 1-week immobilization, range of motion (ROM) of dorsiflexion declined to 90% of the control value; additionally, ROM dropped to 67.5% of the control value after a 3-week immobilization. This finding suggested that ankle joint mobility decreases in conjunction with extended periods of immobilization. Insoluble collagen concentration in soleus muscles, which was unchanged after 1 week of immobilization, increased 3 weeks after immobilization.These results may be indicative of collagen fibers with strong intermolecular cross-links contained in the muscle was made increased relatively by 3 weeks of immobilization. Therefore, the change in intermolecular cross-links may be significant in terms of progress of muscle contracture with longer periods of immobilization. On the other hand, the ratio of type III to type I collagen isoforms in muscular tissue increased following a 1-week immobilization; moreover, this ratio remained constant after 3 weeks of immobilization. These data suggested that muscle immobilization may induce type III collagen isoform expression. The increase in the ratio of type III to type I collagen isoforms do not change in parallel with the increase in the limitation in ROM; however, this phenomenon probably is not closely related to the progress of muscle contracture. The change of collagen isoform in immobilized muscle may be involved in the mechanism governing the progression of muscle fibrosis.
- Japanese Physical Therapy Associationの論文
- 2008-04-29
著者
関連論文
- 173. 歩行による身体動揺の加齢変化
- 369. 筋積分値・平均周波数による筋疲労の解析 : 低強度・持続収縮での検討
- 90. 膝蓋腱採取が大腿四頭筋筋力に及ぼす影響
- 69. Step-Up Exerciseの筋電図学的分析
- 股関節外転筋力訓練の最適肢位に関する一考察
- 315. 股関節外転筋力測定方法における基礎的研究 : 測定肢位と代償運動の関係
- 2.股関節評価基準の検討(第5回 中部リハビリテーション医学会)
- 433. 膝伸展最大筋トルクの低下と仕事量, TAEの関連
- Effect of Immobilization on Insoluble Collagen Concentration and Type I and Type III Collagen Isoforms of Rat Soleus Muscle