Cryoimmunologic Investigations in Patients With Prostatic Carcinoma

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Transurethral cryosurgery was performed with liquid nitrogen in 18 patients with prostatic carcinomas. The clinical course and the effect of cryosurgery on immune competence of patients were observed. After cryosurgery, pain was relieved in 5 of 6 patients, dysuria was improved in 7 of 12 patients, and the prostatic mass was reduced in 14 of 18 patients. Elevated serum acid phosphatase levels returned to normal in 5 cases. Changes of serum protein fractions were variable. Serum complement levels were high in advanced cases. Changes of immunoglobulins were variable. Serum anti-prostatic antibody could not be detected by passive hemagglutination test and by indirect immunofluorescent examination. DNCB skin reaction and blastoid transformation of lymphocytes were raised after therapy. The cellular immune competence may be enhanced by cryosurgery, while the humoral immune competence is scarcely influenced by the therapy. It has been reported that remission of metastatic lesions occured after cryosurgery for advanced prostatic carcinoma (Soanes et al.1)). Furthermore, it was suggested that immune competence of the patient with carcinoma may be enhanced after cryosurgery (Ablin2)). In an attempt to examine the effect of cryosurgery on immune competence, we observed clinical and immunologic responses after treatment in 18 patients with prostatic carcinoma.
1979-10-25