Effect of Acidosis on the Adrenaline Secretory Response of the Adrenal Gland to Splanchnic Nerve Stimulation

概要

論文の詳細を見る
Experiments were performed on dogs anesthetized with sodium pentobarbital. Adrenal venous blood samples were collected through the lumbar route and were analyzed for adrenaline by the arseno-molybdic acid method. The splanchnic nerves were cut below the diaphragm and the peripheral parts were stimulated electrically. Metabolic acidosis was induced by infusion of hydrochloric acid solution into the femoral vein. Splanchnic nerve stimulation caused a definite increase in adrenaline secretion of the adrenal gland before acid infusion. When the blood pH was decreased by acid infusion from 7.34-7.48 to 6.97-7.15, almost the same adrenaline secretory response to the splanchnic nerve stimulation was observed as before acid infusion. When the blood pH decreased considerably and reached a level below 6.72, the adrenaline secretion rate was elevated before stimulation and in most cases it was further increased by splanchnic nerve stimulation.
Nagasaki University School of Medicineの論文