Effect of Anoxia on the Responsiveness of the Adrenal Medulla to Splanchnic Nerve Stimulation

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In dogs anesthetized with sodium pentobarbital, the adrenal venous blood was collected and was estimated for adrenaline by the arseno-molybdic acid method. Simultaneously, arterial blood samples were taken and the blood gas contents were estimated by the manometric method. Anoxia was induced by inhalation of 5.7-7.2 per cent oxygen in nitrogen or 4.4-5.8 per cent oxygen and 1.1-6.7 per cent carbon dioxide in nitrogen. The adrenal medullary response to splanchnic nerve stimulation during low oxygen air inhalation was always found to be greater than during normal air inhalation. It is concluded that the responsiveness of the adrenal medulla to splanchnic nerve stimulation is increased by lack of oxygen.
Nagasaki University School of Medicineの論文
1961-03-00