Reactive Hyperemia in Coronary Blood Flow 1

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The reactive hyperemia induced by a temporary occlusion of coronary circulation was investigated in an isolated cat's heart perfused with blood supplied by a donor. The magnitude of hyperemia was quantitatively proportional to the ischemic periods ranging from 6 to 90 seconds. The pretreatment with atropine as well as dinitrophenol did not affect the reactive hyperemia. Diphenhydramine HCl in a dose reducing the effect of 1.0,μg of histamine decreased the magnitude of hyperemia. After pretreatment with cocaine and procaine the reactive hyperemia was inhibited . Serum potassium level of the coronary outflow collected after the occlusion was significantly increased. These findings suggest that the metabolites involved in the reactive hyperemia may not be acetylcholine, but histamine and potassium which probably produce the dilatation of coronary vessels through an axon reflex.
Nagasaki University School of Medicineの論文