Adult T-cell Leukemia Virus (ATLV) -associated Lymphoma

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An autopsy case of malignant lymphoma presenting T-cell phenotype in life and B-cell phenotype at autopsy is reported. The histology of a biopsy of right cervical lymph nodes in a 56-year-old woman revealed "non-Hodgkin's lymphoma, diffuse, medium-sized cell type". 74.5% of lymphoid cell suspensions formed the spontaneous rosettes with sheep erythrocytes. Proviral DNA of adult T-cell leukemia virus was found after cell fraction. She was treated as adult T-cell leukemia. On the 69th hospital day, however, she died and autopsy was performed. The histology of lymph nodes of the neck at autopsy showed a diffuse proliferation of small to medium-sized neoplastic cells with the interspersed immunoblasts. Electron microscopically, these proliferating neoplastic cells differentiated into the immunoblasts to plasma cells. Also, they showed positivity for the PAP immunostaining method with anti-IgA and x sera.