New approach to the synthesis of non-benzenoid aromatic compounds, functionalized 1-azaazulene derivatives: Cyclization reactions of 2-substituted tropones with N-silylenamine and enamine

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概要

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• The reaction of enamines with 2-subsituted tropones produced functionalized 1-azaazulene derivatives. When the reaction is conducted in an aprotic solvent, such as DMSO, the desired 1-azaazulene was obtained in 51% yield. The introduction of an electron-donating group on the enamine increased its nucleophilicity and improved the product yield. On the other hand, the reaction of enamines with 4-isopropyltropone-2-tosylate afforded a different 1-azaazulene derivative.

• 日本複素環化学研究所の論文

著者

• Sakai Norio

  Dep. Of Pure And Applied Chemistry Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.

• Konakahara Takeo

  Tokyo Univ. Sci. Chiba Jpn

関連論文

• New approach to the synthesis of non-benzenoid aromatic compounds, functionalized 1-azaazulene derivatives: Cyclization reactions of 2-substituted tropones with N-silylenamine and enamine

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