Antianxiety Effect of Ehtyl Loflazepate， CM6912， Assessed by Frontal Medline Theta Activity in Man

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The theta activity which appears in the frontal midline area during performance of mental tasks been designated as Fmθ. In the present atudy, the potency of CM6912 as an anixiolytic was investigated using Fmθas compared with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, CM6912 2 mg and 4 mg in a double-blind, crossover design. Scores were made on the state anxiety scale of Spielberger`s State Trait Anxiety Inventory (STAI), EEDs were recorded before and during performance of an arithmetic addition. The test was repeated twice, before and 1 hr after drug administration. Placebo increased Fmθ ; however, diazepam, CM6912 4 mg only slightly influenced Fmθ. Scores of state anxiety were reduced by diazepam, placebo and CM6912 4 mg, and only slightly by CM6912 2 mg. Task performance was increased by placebo, but wads not affected by diazepam and both doses of CM6912. These results suggest that CM6912 possesses a rather mild anxiolytic effect, and that Fmθmight be a useful tool in precting the clinical efficacy of anxiolytic drugs in normal humans.
Yamaguchi University Graduate School of Medicineの論文