Clinical Application of Measuring Serum Fructosamine as an Index of Glycemic Control in Diabetic Patients
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Measurement of serum fructosamine is a new method for the quantification of glycated serum proteins. We examined the clinical application of measuring serum fructosamine as an index of glycemic control in diabetic patients. Serum fructosamine had good correlation with mean fasting plasma glucose obtained 0-3 weeks before the fructosamine measurement and had best correlation with that obtained 1 week before the measurement (r=0.531, p<0.001). Correlations with mean fasting plasma glucose obtained 4 week before the measurement (r=0.407, p<0.1) or hemoglobin A1 at the nearly same sampling time (r=0.306, p<0.2)were not significant. The patients tested were divided into 4 groups according to diabetic control evaluted from mean fasting plasma glucose obtained 1week before the fructosamine measurement ; an excellent group (<120 mg/dl) ; a good grop (121-140 mg/dl) ; a fair group (141-160 mg/dl) ; a poor group (>161 mg/dl). Mean value of serum fructosamine in an excellent group was significantly higher than that in healht controls (p<0.05), and increased according to worseing of glycemic control, and that in a poor group was significantly higher than that of an exellent group (p<0.001). These results suggested that measurement of serum fructosamine is useful as amedum term (0-3 weeks) index of glycemic control in diabetic patients, especially who have had a rapid flucuation in glycemic control for a couple of weeks.
- Yamaguchi University Graduate School of Medicineの論文
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