Anacardic Acids and Ferric Ion Chelation
スポンサーリンク
概要
- 論文の詳細を見る
6-Pentadeca(e)nylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae), commonly known as anacardic acids, inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively without prooxidant effects. Their parent compound, salicylic acid, did not have this inhibitory activity up to 800 μm, indicating that the pentadeca(e)nyl group is an essential element to elicit the activity. The inhibition is attributed to its ability to chelate iron in the enzyme. Thus, anacardic acids chelate iron in the active site of the enzyme and then the hydrophobic tail portion slowly begins to interact with the hydrophobic domain close to the active site. Formation of the anacardic acids-ferric ion complex was detected in the ratio of 2:1 as the base peak in the negative ion electrospray ionization mass spectrometry. Hence, anacardic acids inhibit both E_<ox> and E_<red> forms.
- Verlag der Zeitschrift für Naturforschungの論文
- 2007-00-00
Verlag der Zeitschrift für Naturforschung | 論文
- Zoosporicidal activities of anacardic acids against Aphanomyces cochlioides.
- Controlling Engine System : a Low-Dimensional Dynamics in a Spark Ignition Engine of a Motorcycle
- Anacardic Acids and Ferric Ion Chelation
- Isolation of enantiomeric type sesquiterpenoids from the liverwort Riccardia jakii.
- Evaluation of Lipoxygenase Inhibitory Activity of Anacardic Acids