A case of Maxillary Sinus Plasmacytoma and Analysis of Cellular Biological Features

概要

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Extramedullary plasmacytoma is a rare malignant tumor that generally arises in the head and neck region. We encountered a plasmacytoma located in the maxilla, maxilllary sinus, and ethmoidal sinuses. The tumor was composed of premature cells showing positive staining for λlight chain immunoglobulin. Several types of examination, including M protein analysis, reled out multiple myeloma. After a debulking operation, a total of 50 Gy of radiation failed to shrink the tumor. To prevent the tumor from progressing to multiple myeloma, the patient underwent chemotherapy. After this treatment, the tumor showed no growth. Flow cytometry and comparative genomic hybridization studies showed the tumor DNA to be diploid, containing few chromosomal aberrations. On the basis of these findings, it was thought that the tumor malignancy of plasmacytoma might be relevant to DNA ploidy pattern and chromosomal aberration.
Yamaguchi University Graduate School of Medicineの論文