アルブミンに対するアフェレシス : アルブミンを利用したアフェレシス療法の展開(<特集>アフェレシス技術の進歩・普及・教育)

概要

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In various pathologies, essential function of albumin drop due to various reasons including change in quantity and quality of albumin and accumulation of albumin binding toxins (ABT), and as a result, weakening of homeostasis in the body has been caused. In particular, accumulation of ABT causes not only indirect but also direct harmful influence. Albumin has the ability to bind with multiple molecules, albumin containing bicarbonate dialysate (albumin dialysate; AD) was applied for dialysis, and this dialysis with AD and high-flux membrane has been developed as a new blood purification technology. This blood purification technology is named extracorporeal albumin dialysis (ECAD). ECAD was effective for selective removal of ABT. Among ECAD methods, Molecular Adsorption in a Recycling System (MARS^[○!R]) might have the largest application for clinical use. The indications for MARS^[○!R] include acute-on-chronic liver failure and drug intoxication. However, since various matters regarding ABT including clinical effects still remains unclear, more studies are required in the future. The establishment of effective methods for eliminating ABT and a simple measurement method of ABT are also needed.
2014-02-28