Salinomycin Sensitizes Melanoma Spheroids Containing Slow-Cycling Cells to the Effects of Arsenic Trioxide
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概要
- 論文の詳細を見る
Recurrence after chemotherapy is a major cause of cancer mortality : subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.
- 秋田大学の論文
- 2014-03-31
著者
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Manabe Motomu
Department Of Dermatology Akita University School Of Medicine
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Ishikawa Norihisa
Department Of Applied Chemistry College Of Engineering Chubu University
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Noguchi Natsuko
Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine
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Takahashi Mayuko
Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine
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