P36 白血病細胞に対するメガヘルツ超音波の抗腫瘍効果(ポスターセッション)

概要

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Recently, ultrasound has been a lot of attention in medical field. Its widely usage in surgical treatment fields such as high intensity focused ultrasound (HIFU) and drug therapy fields such as drug delivery system (DDS) has become an important issue. Relationship between cavitation-induced OH radical and cell killing after ultrasound irradiation was investigated in order to evaluate the proper therapeutic effect and the safety of MHz ultrasound. Irradiation was performed for 10 seconds at 1.6, 2.4, 5.4 and 7.9MHz, respectively. Considering cell damage in normal tissue, we examined the effect of ultrasound on proliferation of human myelomonocytic lymphoma cell line U937 cells. In addition, we analyzed the induction of apoptosis after irradiation using phosphatidylserine externalization. As a result, we clarified that the variation of MHz ultrasound frequency altered the induction of cell damage and the generation of hydroxyl radicals. We also confirmed that hydroxyl radical scavengers did not disturb the collapse of cells during ultrasound irradiation.
日本ソノケミストリー学会の論文
2013-10-25