Lp(a) Apheresis, Endothelial Dysfunction and Potential for Extracorporeal Correction(Workshop1-12)

概要

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Endothelial dysfunction has been shown to correlate inversely with Lp(a) levels in children with familial hypercholesterolaemia (FH) as assessed by quantifying endothelium - dependent vasodilatation. The object of this pilot study was to ascertain whether removal of Lp(a) by Lp(a) apheresis might restore impaired endothelial dysfunction in FH patients with a high Lp(a) level. During the study, mean in-trial Lp(a) levels in the apheresis group were lower than that of the control, while mean LDL levels remained unchanged in both groups. In the apheresis group flow mediated vasodilatation increased from 0.5 % to 6 % but did not change in the controls.
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