P30 酸化チタンと超音波による生物学的応用(ポスターセッション)

概要

論文の詳細を見る
Titanium dioxide (TiO_2), have high reactive potential by photoexcitation, had been investigated its medical use for anticancer therapy. However, TiO_2 has a pKa around 6.6, these particles are unstable at neutral pH, and it tends to aggregate. This problem makes it difficult to use for medical practically. We developed a very stable nanocomposites, it consist of the TiO_2 and the hydrophilic polymers (TiO_2 nanocomposites). It was synthesized by heat reaction in DMF, could disperse even in 10% protein containing aqueous solution. Previously, we reported the anticancer activity of the TiO_2 nanocomposites by UV irradiation. In this work, we investigated both the radical generation and the killing effect of the TiO_2 nanocomposites by ultrasonic irradiation especially at a high frequency, which is well used for medical diagnosis. The generation of reactive oxygen species and the killing effect are enhanced in the presence of TiO_2 nanocomposites by ultrasonic irradiation. On the other hand, in the presence of P25 particle or absence of TiO_2 particle neither enhancement of radical generation nor killing effect. Thus, it seemed that the radical generation and/or the killing effect are strongly related to properties of particles (ie., size, surface charge). In conclusion, TiO_2 nanocomposites has potential that is suited for this new anticancer therapy system.
日本ソノケミストリー学会の論文
2006-10-27