A20 診断・治療両用超音波造影剤に関する研究

概要

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We propose the use of nano-sized emulsion systems which change their phase from liquid to gas, generating microbubbles, upon exposure of ultrasound pulses for site-specific ultrasound contrast agent. They also have potentials to be used for sensitizers in ultrasonic therapies. In in vitro experiments, it was confirmed that our nano-sized emulsion system changes its phase by ultrasound exposure at relatively low acoustic intensity (less than 10W/cm2). Further, in vivo experiments using subcutaneously implanted murine tumor showed that the phase can be shifted by ultrasound exposure under the same conditions as above in vitro experiments. It was also found that focused ultrasound at an acoustic intensity of 40W/cm2 contiguously exposed after the phase shift is established in the tumor tissues induce therapeutic effects at the focus. Our results indicated the potential usefulness of the nano-sized emulsion system as a versatile agent for ultrasonic diagnosis and therapy. Part of this work was supported by the Japanese Ministry of Education, Culture, Sports, Science and Technology through a grant-in-aid for the creation of innovations through business-academic public sector cooperation.
日本ソノケミストリー学会の論文
2005-10-14