206 粘弾性3要素モデルを用いたヒト赤血球の動的変形能評価に関する研究

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An erythrocyte is represented using viscoelastic model with two degrees of freedom that spring is connected parallel to dashpot to estimate dynamic deformability quantitatively. To identify such parameters as an elastic modulus and viscous damping coefficient of the model, erythrocytes were deformed in the experiment using periodical share flow field. In this research, we used erythrocytes of normal subject, and changing deformability of some erythrocytes was provided glutaraldehyde to treat hardening treatment. The displacement of the center of gravity ΔG and the deformation quantity of major axis ΔL are obtained from time series of images. Both of the data are periodic on movement and deformation of erythrocytes. Based on the experimental data, parameters of viscoelastic model were identified. The estimation method of dynamic deformability about erythrocytes was examined. In the result, it was found that dynamic deformability of human erythrocyte can be estimated using viscoelastic model with three elements. And the simulation results using three elements model simulated experimental results more particularly than two elements model.
2011-09-05