Biotransformation of 14-deoxy-14-methylenetriptolide into a novel hydroxylation product by Neurospora crassa(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
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The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide.
著者
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Li Ji'an
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry
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Qin Jihong
Shanghai HuiLun Life Science & Technology Co. Ltd
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Fan Xing
Shanghai HuiLun Life Science & Technology Co. Ltd
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Shao Lei
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry
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Chen Zhouzhou
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry
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Lin Huimin
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry
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Dong Xiaojing
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry
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Chen Daijie
The State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Institute of Pharmaceutical Industry