サイトカインの生成・遊出に対するビタミンEサプリメントの効果と遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンE-)

概要

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Cytokines are critical regulators in immune responses and inflammation. Vitamin E (VE), α-tocopherol, is known to improve immune function, especially in the elderly, and to exert anti-inflammatory action in part by altering the production and release of cytokines. However, several large cohort and clinical intervention studies have shown that supplemental VE does not always exert its immunomodulatory and anti-inflammatory effects in healthy people and patients with diseases such as atherosclerosis and infections in which impaired immune function and inflammation participate. As one of the reasons, it has been assumed that an individual's genetic background affects the response to VE supplementation under conditions of impaired immune function and inflammation. Recent several studies have suggested that the effect of supplemental VE on impaired immune function and inflammation is dependent on an individual's single nucleotide polymorphism at cytokine genes. In this mini review, the relationship between the effect of supplemental VE on the production and release of cytokines and polymorphism has been discussed.
2013-07-25