A Dipstick Test Combined with Urine Specific Gravity Improved the Accuracy of Proteinuria Determination in Pregnancy Screening

概要

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Proteinuria screening using a semi-quantitative dipstick test of the spot urine inantenatal clinic is known to have high false-positive rates. The aim of this study was toassess availability of a dipstick test combined with the urine specific gravity for thedetermination of pathological proteinuria.A dipstick test was performed on 582 urine samples obtained from 283 pregnantwomen comprising 260 with normal blood pressure and 23 with pregnancy-inducedhypertension. The urine protein (P) and creatinine (C) concentrations, specific gravity(SG), P/C ratio were determined, and compared with dipstick test results.The P concentration increased along the stepwise augmentations in dipstick testresult. Frequencies of the urine samples with 0.265 or more P/C ratio were 0.7% with -dipstick test result, 0.7% with the ± result, 3.3% with the 1+ result, and 88.9% with the≥2+ result. However, if the urine specific gravity was low, frequencies of the high P/Cratio were 5.0% with ± dipstick test result and 9.3% with the 1+ result.A dipstick test result of ≥2+ seems appropriate for a criterion of positive screeningfor pathological proteinuria in antenatal care. A dipstick test combined with the urinespecific gravity may be useful for outpatient clinic screening.
神戸大学の論文
2010-00-00