動脈硬化とAGE/RAGE/ADMA system(<特集>動脈硬化とアフェレシス)

概要

論文の詳細を見る
Landmark clinical studies have substantiated the concept of 'metabolic memory' in the pathogenesis of cardiovascular disease (CVD) in diabetes. Indeed, the DCCT-EDIC Research and UKPDS80 Group have revealed that beneficial effects of intensive therapy on vascular injury in diabetic patients are sustained after the cessation of the trials. These observations suggest that chronic abnormalities in diabetic vessels that are not easily reversed, even by subsequent, relatively good control of blood glucose. Among various biochemical pathways, the process of formation and accumulation of advanced glycation end products (AGE) and their mode of action are most compatible with the theory of 'metabolic memory'. Furthermore, there is accumulating evidence that AGE, their receptor RAGE and asymmetric dimethylarginine (ADMA) system plays an important role in CVD in diabetes. These observations suggest that the blockade of the AGE/RAGE/ADMA axis may be a promising therapeutic target for CVD in diabetes. In this paper, we review the pathological role of the AGE/RAGE/ADMA system in accelerated atherosclerosis in diabetes.
2013-02-28