ホモシステイン代謝における水溶性ビタミンの機能(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,<特集>ビタミン基礎研究の進展を担う若手研究者たち(第64回大会若手シンポジウム))
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Homocysteine is a non-protein-constituting amino acid. It is, however, one of the well-known amino acids as a biomarker. Hyperhomocysteinemia is a condition characterized by an elevated level of homocysteine in blood. Since hyperhomocysteinemia is reported as an independent risk factor for cardiovascular disease, a number of researches related to homocysteine metabolism have been reported. Many water-soluble vitamins act as a cofactor for homocysteine metabolism. Homocysteine is a metabolite of methionine, and it is involved in highly regulated folate and methionine metabolism. In this metabolism, homocysteine is one of the key metabolites. In this review,the function of vitamins in this important metabolism is described; especially focused on two enzymes, methionine synthase and methylenetetrahydrofolate reductase.
- 2013-01-25
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関連論文
- ホモシステイン代謝における水溶性ビタミンの機能(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,日本ビタミン学会第64回大会講演要旨)
- ホモシステイン代謝における水溶性ビタミンの機能(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,ビタミン基礎研究の進展を担う若手研究者たち(第64回大会若手シンポジウム))