多剤耐性アシネトバクターのリスク因子解析を目的とした症例対照研究の方法論に関する研究

概要

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Objective: The aim of this study is to assess methodological principals of adaptation to case-control studies that analyzed risk factors for acquisition of multidrug-resistant Acinetobacter baumannii. Methods: A systematic review was conducted for articles published from 2001 through 2010. Following methodological principals were evaluated and classified depending on the study purpose: method of case and control group selection, adjustment for time at-risk and comorbidities, and separate analysis of different resistance mechanisms. Results: A total of 261 abstracts were reviewed and twenty-four studies met the inclusion and exclusion criteria. Eighteen studies (75%) chose preferred case and control group, respectively. Fifteen (63%) adjusted for time at-risk and sixteen (67%) adjusted for comorbidities. Two studies (8%) conducted separate analysis of each resistance mechanism. Conclusions: No study were found to adapt all methodological principals, however case and control selection should be considered to apply at all times. All associated adjustment variables for time at-risk and comorbidities should also be examined, among which final adjustment variables need to be selected appropriately in accordance with each study.
2012-10-00