Tsukuba 情動系ラットの空間的作業記憶能力の検証

概要

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So far, the spatial learning ability of Tsukuba emotional strain rat was examined using the water maze which needed only reference memory and eight-arm radial maze that needed both working memory and reference memory. As a result, the performances of Tsukuba low emotional strain (L) rat were worse than those of Tsukuba high emotional strain (H) rat only in eight-arm radial maze task, and then the working memory disturbance of the L rat was suggested. The present study inserted a delay problem by eight-arm radial maze learning process, in order to verify more strictly the working memory ability in both H and L rat. Obtained results summarized as follows; although the number of the trials until insertion of the delay problem in L rat were less than those in H rat, the false choice rate in the flrst choice after the flve-minutes delay was higher, and the number of the trials until the learning criterion signiflcantly increased in L rat, and then the working memory disturbance of the L rat became clearer. And it was thought that the cause of the spatial learning disturbance of L rat might be a deflcit of the working memory capacity.
2013-03-31