Development of macrolide lactone antibiotic brefeldin A fermentation process with Eupenicillium brefeldianum ZJB082702(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
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In this work, a robust brefeldin A-synthesizing fungus, Eupenicillium brefeldianum ZJB082702, was bred from a Murraya paniculata endophytic fungus E. brefeldianum A1163. Using one-factor-at-a-time experimental design, optimization of media composition for E. brefeldianum ZJB082702 fermenting brefeldin A was conducted. Outcomes indicated that mixed carbon source and mixed nitrogen source were of c ritical importance to brefeldin A fermentation. After 6 d culture in the optimized fermentation media, composed of (gl^<-1>) 13.33 starch, 26.67 glucose, 1.0 yeast extract powder, 1.0 corn steep liquor, 0.5 soybean meal, 0.75 NaNO_3, 2.5 malt extract, 6.0 CaCO_3, 3.0 MgSO_4, 4.0 KH_2PO_4, 1.0×10^<-2> CuSO_4, brefeldin A yield peaked at 1304.7 mgl^<-1>, 648.2 mgl^<-1> in 500 ml baffled flask and 15 l stirred fermentor respectively, formed as a growth associated type of secondary metabolite based on fermentation profile analysis.
著者
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Zheng Yu-guo
Institute Of Bioengineering Zhejiang University Of Technology:engineering Research Center Of Bioconversion And Biopurification Of The Ministry Of Education Zhejiang University Of Technology
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Wang Ya-jun
Institute Of Bioengineering Zhejiang University Of Technology:engineering Research Center Of Bioconversion And Biopurification Of The Ministry Of Education Zhejiang University Of Technology
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Wu Ye-fei
Institute Of Bioengineering Zhejiang University Of Technology:engineering Research Center Of Bioconversion And Biopurification Of The Ministry Of Education Zhejiang University Of Technology
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Xue Feng
Institute Of Bioengineering Zhejiang University Of Technology:engineering Research Center Of Bioconversion And Biopurification Of The Ministry Of Education Zhejiang University Of Technology
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Xue Ya-ping
Institute Of Bioengineering Zhejiang University Of Technology:engineering Research Center Of Bioconversion And Biopurification Of The Ministry Of Education Zhejiang University Of Technology
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- Development of macrolide lactone antibiotic brefeldin A fermentation process with Eupenicillium brefeldianum ZJB082702
- Development of macrolide lactone antibiotic brefeldin A fermentation process with Eupenicillium brefeldianum ZJB082702(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Development of macrolide lactone antibiotic brefeldin A fermentation process with Eupenicillium brefeldianum ZJB082702