Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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概要

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• The purpose of this paper is to describe the glycosylation of entacapone by cultures of Cunninghamella echinulata ATCC 9245. This method is then applied in toxicological and pharmacological studies. The cultures were grown in a fluid PDSM medium for 7 days at 28℃. After purification by silica gel flash column chromatography, the (E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-nitro-5-(3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)phenyl) acrylamide was identified by IR, mass spectroscopy and ^1H and ^<13>C NMR. The correct position and β-configuration of the glucose was determined through HSQC, HMBC and NOE experiments.

著者

• Liao Luciano

  Laboratorio De Ressonsncia Magnetica Nuclear Instituto De Quimica Universidade Federal De Goias Campus Samambaia

• Braga Rodoipho

  Laboratorio De Bioconversdo Faculdade De Farmacia 1^<a___> Avenida Esquina C/ Praca Universitaria

• Lustosa Keyla

  Laboratorio De Bioconversao Faculdade De Farmacia 1^<a___> Avenida Esquina C/ Praca Universitaria

• Liao Luciano

  Laboratorio De Ressonancia Magnetica Nuclear Instituto De Quimica Universidade Federal De Goias Campus Samambaia

• Menegatti Ricardo

  Laboratorio De Quimica Farmaceutica Medicinal Faculdade De Farmacia

• Menegatti Ricardo

  Laboratorio De Quimica Farmaceutica Medicinal Faculdade De Farmacia 1^<a___> Avenida Esquina C/ Praca Universitaria

• Oliveiral Valeria

  Laboratorio de Bioconversdo, Faculdade de Farmacia, 1^ Avenida esquina c/ Praca Universitaria

• Oliveiral Valeria

  Laboratorio De Bioconversdo Faculdade De Farmacia 1^<a___> Avenida Esquina C/ Praca Universitaria

• Braga Rodolpho

  Laboratorio De Bioconversao Faculdade De Farmacia

関連論文

• Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245

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