The effect of implementing objective functions in analyzing the changes of enzyme activity profiles

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概要

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• To maximize the target metabolic fluxes, the use of an objective function in determining the Elementary Mode (EM) Coefficients (EMCs) somehow gives some impacts. This paper describes the effect of applying the objective function, i.e., Maximum Entropy Principle (MEP), on estimating the EMCs. MEP is applied to the Gene Modification of Flux (GMF) [1] [2] - a method that uses the elementary modes of a metabolic network map to predict its associated flux distribution under different genetic conditions.

• 2012-08-02

著者

• Hiroyuki Kurata

  九州工業大学大学院情報工学府生命情報工学分野

• Soma Tabata

  九州工業大学大学院情報工学府生命情報工学分野

• Kentaro Inoue

  九州工業大学大学院情報工学府生命情報工学分野

関連論文

• The effect of implementing objective functions in analyzing the changes of enzyme activity profiles

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