Immune function in a patient with aspergillosis after lung transplantation: Case Report

概要

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We report a case that was successfully treated invasive pulmonary aspergillosis after living donor lobar lung transplantationand monitored patients' immune function with ImmuKnow® assay. A 43-year-old woman underwent living donor lobar lungtransplantation for pulmonary alveolar proteinosis. Two healthy her relatives donated each lower lobe. Six months after transplantation,she was diagnosed as invasive pulmonary aspergillosis (IPA). During the anti-fungal treatment, one immunosuppressantwas withdrawn and the trough level of calcineurin inhibitor was reduced to the minimum. Despite of such a lowimmunosuppressive status, Immuknow® assay showed that immune function was maintained in the moderate range, whichencouraged us to keep this strategy for IPA. Immune evaluation by Immuknow® is useful method for monitoring and controllingpatients' immune status especially in the infected condition, which revealed moderate immune level could be maintained withonly two immunosuppressant drugs in the patient after recovery from IPA.