遺伝子診断教育のための簡便な毛髪形態(EDAR)及び耳垢型(ABCC11)遺伝子多型解析法
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概要
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Recently, progress in molecular biology is being made in various fields such as biology, agriculture andmedical and pharmaceutical sciences. Students graduating from not only pharmaceutical departments butalso general high schools will be required to have knowledge of molecular biology techniques for understandingprevailing technologies. However, it is difficult to include such experiments in a curriculum for studentsat general high schools and universities because of safety aspect, expensive materials and experimentalequipment and time consumed. This report introduces the convenient experimental methods on human DNApolymorphisms for the genotyping of the hair thickness-determining gene EDAR on the chromosome 2 andthe earwax type gene ABCC11 on the chromosome 16 using a PCR-RFLP method. This experiment enableseach student to handle DNA safely. The total experiment time is less than 6 hours. The PCR-RFLP experimentproposed here is a suitable genotyping method to acquire molecular biological knowledge and techniques.